The Histology Core Facility at the Dental School specializes in sectioning of hard (demineralized) tissues. The Core offers basic histology and staining. Paraffin and frozen histology are also available.

At the MicroCT Core, Scanco µCT 100 micro-computed tomography system provides high resolution scans of radio opaque specimens such as bone, contrasted soft tissue, bio materials, etc.

The Molecular Biology Core is a School of Dentistry sponsored, biotechnology core facility which has been serving our research community since 2001. We provide real-time quantitative PCR (ViiA7, 7500 instruments).

The HomeLab offers a fully functional apartment to facilitate whole-systems human-centered research in a wide variety of contexts such as: care-at-home, physical rehabilitation, internet of things, aging in place, etc.

The Center for Structural Biology (CSB), housed in the Life Sciences Institute, is a comprehensive structural biology resource for researchers at the University of Michigan and surrounding areas.

The U-M Life Sciences Institute is home to a world-class cryo-EM laboratory, with state-of-the-art instruments and faculty specializing in this emerging field.

The Center for Chemical Genomics provides high-throughput screening of extensive small molecule, natural product and siRNA libraries – along with assay development and optimization – for basic biology and drug discovery projects.

The University of Michigan Natural Products Discovery Core (NPDC) has developed a 40,000-sample (and growing) library of natural product extracts derived from a unique collection of diverse marine and terrestrial actinomycetes, fungi and cyanobacteria.

State of the art NMR instruments provide the ability to obtain structural, dynamic and kinetic information on biological macromolecules including protein, RNA and DNA. Automated sampling devices also make it ideal for metabolomics and high throughput data collection.

The Animal Studies Core (ASC) aims to provide expertise and services to basic biomedical researchers using rodent models to study processes relevant to diabetes, its complications, and related endocrine and metabolic disorders.

The CMI is a shared resource aimed at providing state-of-the-art imaging services for the research community. The CMI is a central, diverse, and dynamic combination of facilities wherein exchange of techniques and ideas can occur, fostering productive interdisciplinary collaborations in research.

The CyTOF Core at the University of Michigan was founded in 2018 to promote a collaborative and interdisciplinary environment on the University of Michigan’s North Campus. Our goal is to share our equipment and expertise with ambitious researchers to help solve the most challenging problems in cellu

The Experimental Irradiation Core specializes in moderate dose (0.1-4 Gy/min) and low dose irradiation (0.05-0.3 Gy/hr) of cell cultures, tissues and animals.

The Hybridoma Core generates somatic-cell hybrids (hybridomas) that produce monoclonal antibodies of desired specificity. The Core offers state-of-the-art monoclonal antibody technologies and services to biomedical research investigators.

The Rogel Cancer Center Immunology Core provides research assistance to members of the university, with priority given to Rogel Cancer Center members.

<p>IVAC provides necropsy/tissue collection, animal hematology and clinical chemistry, histology and immunohistochemistry slide preparation, digital slide scanning and quantitative analysis, and pathology interpretation on a fee-for-service basis for non-clinical (animal), non-GLP studies on campus.</p>

The Michigan Diabetes Research Center's Chemistry Laboratory is a clinical core providing many assays related to diabetes, heart disease, and hypertension.

The overall objective of the Nutrition, Exercise and Phenotype Testing (NExT) Core is to enhance and expand the research capabilities of investigators performing clinical and translational studies related to nutritional interventions, obesity, or obesity-related disorders in humans.

The nano- and micro-CT facility core provides services for acquiring three-dimensional imaging and quantitative analysis of biological and engineered structures/materials. The core is capable of imaging mineralized tissues and soft tissues with the aid of radiographic contrast agents.

The Microbiome Core provides services and resources to microbiome researchers from across campus and beyond. These services include microbial community analysis, microbial cultivation, germ-free & gnotobiotic mouse facilities, and the strain collection database.

The MICP Core provides state-of-the-art protein and RNA imaging and cell physiological analysis to enhance the diabetes-related research at the University of Michigan.

The Molecular Genetics Core of the Michigan Diabetes Research Center provides services related to the application of genetic methodologies to research questions related to diabetes.

Enhancing existing research by centralizing histologic efforts to achieve high quality and reasonably priced histology for center investigators, and to ensure, in collaboration with the other Cores, a cost-effective, efficient, integrated, hierarchical approach to evaluation of tissue phenotypes.

The goal of the PRF is to assist researchers in designing proteomic experiments, maintain state-of-the-art instrumentation, provide technical expertise and bioinformatics support during both discovery and validation phases of proteomic experiments.

The Single Cell Analysis Resource aims to help researchers explore molecular aspects of cellular heterogeneity, population diversity, and complexity within single cell samples prepared from tissues, biological fluids (e.g. blood), tumors and cultured cell lines.

The sIRB centralizes the regulatory review of the human research activities taking place at all of the participating sites for a project. The type of IRB application used for the sIRB review of a cooperative research study varies.

The Tissue and Molecular Pathology Core consists of several distinct, yet complementary services, all relating to the procurement and evaluation of tissue for research. The Core provides procurement of surgically resected neoplastic and non-neoplastic tissue (fresh and frozen).

The Central Biorepository, a unit of the University of Michigan Medical School Office of Research, facilitates discovery and improves healthcare outcomes by providing high-quality, highly annotated human biospecimens donated for basic, clinical and translational research.

The University of Michigan Advanced Genomics Core Genomic Analysis Services, part of the Biomedical Research Core Facilities within the Medical School Office of Research, provides high-quality, low-cost DNA analysis for research clients on a recharge basis.

The BRCF Bioinformatics Core provides bioinformatics analysis to support research activities.

The BRCF Biomedical Research Store provides on-site procurement of enzymes, reagents, and kits used in molecular, cell biology, and some protein chemistry.

The BRCF Epigenomics Core provides sample quality control, library preparation, and sequencing for the study of cytosine and histone modifications.

The BRCF Flow Cytometry Core provides instrumentation and expertise for flow cytometric analysis or cell sorting.

The BRCF Metabolomics Core provides determination of small quantity metabolites in cells, tissues, and biological fluids.

The BRCF Microscopy Core provides instrumentation and expertise for microscopic imaging studies of cell and tissue morphology and ultrastructure.

The Proteomics & Peptide Synthesis Core offers research services in qualitative and quantitative proteomics including Pathway Analysis. We are a full-service core and provide expert services from project consultation all the way to data analysis, interpretation and software training.

The BRCF Transgenic Animal Model Core provides expertise in CRISPR/Cas9 in transgenic mice, rats, and embryonic stem cell technology.

The Vector Core produces gene transfer vectors that facilitate the transfer of specific genes into either normal or aberrant cells. We also provide full service gene editing in cell lines using CRISPR technology.

The Biochemical Nuclear Magnetic Resonance (BNMR) Laboratory provides research support for graduate students, postdocs, and faculty. We offer quantitative metabolomics NMR services for different biological fluids including whole blood, serum, plasma, urine, cell media.

The Michigan Performance Research (MiPR) Laboratory helps elite athletes and everyday exercisers achieve their personal best. The lab investigates the biomechanics of human movement with the intention of optimizing potential, performance, and functionality.

The Academic IT Core offers a set of specialized IT services designed with our research community in mind. The Core is unique as the services will be available on-demand for a recharge rate outside of the typical IT budget cycle.