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UMICH Experimental Irradiation

Overview of Services

The Experimental Irradiation Core specializes in moderate dose (0.1-4 Gy/min) and low dose irradiation (0.05-0.3 Gy/hr) of cell cultures, tissues and animals. The core has expertise in monitoring DNA damage using laser microirradiation.  The core features 3 orthovoltage units across 3 campus locations.  The core provides metered isoflurane for animal anesthesia during irradiation. In addition, the core now features the SARRP (Small Animal Radiation Research Platform) which permits bioluminescence and CT-guided delivery of radiation to animals. 

The specific goals of the Irradiation Core are to: 

  • Support studies in the radiation biology of moderate dose rate irradiation of cell cultures and small animals, such as mice, rats, and rabbits.
  • Permit the study of low dose rate irradiation in cell culture.
  • Provide irradiation services for investigators whose primary interests are not in radiation biology, but who need this tool in support of other efforts (for example, immunosuppression of animals prior to stem cell transplantation through total body irradiation).
  • Facilitate study of the cellular responses to DNA damage utilizing laser microirradiation as a tool. 
  • Provide state-of-the-art CT and bioluminescence imaging-based radiation delivery to animals.

For questions about the Experiemtnal Irradiation Core or the project you are working on, contact David Karnak

Leadership

Meredith Morgan, PhD | Director

David Karnak, PhD | Manager

Location and hours of operation

Hours Location

 

4310 Med Sci I,
D714 BSRB,
B026-G11N NCRC and
3504E ARF Med Sci I

Links and Resources

  1. Experimental Irradiation Shared Resources

Contacts

Name Role Phone Email Location
David Karnak
Managing Director
 
734-645-2205
 
karnakd@med.umich.edu
 
4326D Med Sci 1