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UMICH Animal Studies Core

Overview of Services

The Animal Phenotyping Core Our Mission: To offer researchers the ability to perform advanced, standardized, metabolic phenotyping studies using a variety of animal models. To provide efficient, low cost project execution and data analysis performed by our staff. To offer consultations involving the design, execution, and analysis of metabolic-related studies in rodents. To maintain an innovative and technologically advanced research core in order to provide the best service to investigators.

The Islet Isolation laboratory offers different services: rat or mouse islets isolation, islet perifusion, insulin, glucagon, Ki67 and TUNEL immunostaining and β- and α-cell mass and proliferation/apoptosis quantification. In situ imaging of fluorescent islets in appropriatley labeled getically engineered mouse models.

For islets, investigators can provide the mice (ULAM needs to be notified several days ahead of time for such transfers), or we can directly order them for an additional cost from approved vendors (e.g., Jackson Labs). Depending on the needs of the investigators, the islets are then either immediately used for RNA or protein extraction or cultured overnight in RPMI culture media with 10% serum. An additional option is that we can now perform perifusion studies which allow the continuous monitoring of the dynamic islet responses to acute changes in glucose levels or in response to a secretagogue of the investigators choice.

The Neural Control of Metabolism Core Coming soon in early 2021, will provide access to custom equipment, techniques, and expertise that can be used assess the role of specific neuronal populations in physiology and behavior. These techniques include in vivo intracellular calcium measurements with fiber photometry to monitor neuronal activity and in vivo optogenetic manipulation of cell activity in awake freely moving animals. NCOM studies will take advantage of the novel genetic models developed within the individual PI. 

Leadership

Animal Phenotyping Core:      
Malcolm Low, MD, PhD Mi-MMPC Director 734-647-1350 mjlow@med.umich.edu
Nathan Qi, MD, PhD Core Director 734-232-8223 nathanqi@med.umich.edu
Melanie Schmitt, MHA Lab Manager 734-764-7043 mlschmi@med.umich.edu
Islet Core:      

Mehboob A. Hussain, MD

Corentin Cras-Meneur

Core Director

Core Manager

 

734-232-8165

mehboobh@med.umich.edu

corentin@med.umich.edu

NCOM:      

Paula Goforth, PhD

Director   pgoforth@umich.edu

Location and hours of operation

Animal Phenotyping Core:

Hours Location

 Monday - Friday 
 8:00 AM - 5:00 PM  

 NCRC B020-30C
 2800 Plymouth Road
 Ann Arbor, MI, 48105

Islet Core:

Hours Location

 Monday - Friday 
 8:00 AM - 5:00 PM  

 NCRC Buidling 20 Room 226W-C 
 2800 Plymouth Road
 Ann Arbor, MI, 48109

NCOM:Coming soon in early 2021

Hours Location

 Monday - Friday 

 

 

Links and Resources

  1. https://mmpc.med.umich.edu/cores/metabolism-bariatric-surgery-and-behavior-core
  2. MDRC - Animal Studies Core (ASC)
  3. Michigan Mouse Metabolic Phenotyping Center (MMPC)
  4. MDRC - Neuronal Control of Metabolism Laboratory (NCOM)
  5. Islet Isolation Laboratory

Contacts

Name Role Phone Email Location
Malcolm J. Low, MD, PhD
Michigan Mouse Metabolic Phenotpying Center and Animal Phenotyping Core Academic Director
 
734-647-1350
 
mjlow@umich.edu
 
Brehm 6116
 
Nathan Qi
Animal Phenotyping Core Director
 
734-232-8223
 
nathanqi@med.umich.edu
 
NCRC B20, Rm 30C
 
Mehboob A. Hussain, MD
Islet Core Scientific Director
 

 
mehboobh@med.umich.edu
 
NCRC B20 231W
 
Corentin Cras-Meneur
Islet Core Director
 
734-232-8165
 
corentin@med.umich.edu
 
NCRC 20-226W-C
 
Paula Goforth, PhD
NCOM Director
 

 
pgoforth@umich.edu