UMICH Microscopy Core

The Microscopy Core provides advanced microscopes as well as the expertise of dedicated imaging scientists.  We can assist you with every step of the imaging process, from sample preparation through quantitative image analysis.

Our website provides a complete description of core's locations, instruments, policies, and rates.

Major Capabilities:

• High speed live cell imaging
• Super resolution imaging
• Large volume 3D imaging
• Intravital imaging
• Tissue clearing and expansion microscopy
• Conventional TEM sample preparation and TEM imaging at Microscopy Core
• Conventional SEM sample preparation and SEM imaging at Microscopy Core
• Negative staining and TEM imaging at Microscopy Core
• Immuno TEM sample preparation at Microscopy Core
• TEM tomography sample preparation at Microscopy Core
• TEM tomography imaging at MC2
• SEM array tomography sample preparation at Microscopy Core 
• SEM array tomography imaging at Microscopy Core
• Focused Ion Beam SEM sample preparation at Microscopy Core
• Focused Ion Beam SEM imaging at MC2
• High pressure freezing and freeze substitution at Microscopy Core
• Tokuyasy cryosectioning for immunolabeling 
• Correlative light and electron microscopy at Microscopy Core
• Full support for image analysis

Major Instruments:

• Nikon X1 spinning disk confocal
• Nikon N-SIM
• Nikon A1si confocals
• Leica SP8 confocal + STED
• Leica SP5 confocals + FLIM
• Leica SP5 multiphoton
• Jeol JEM-1400 Plus TEM (W filament)
• Zeiss EVO 15 SEM (LaB6 filament) 
• EM sample preparation equipment
• Leica EM ACE600 high vacuum coater
• Lecia EM CPD300 critical point dryer
• Leica EM TRIM 2 trimmer
• Leica EM UC7 ultramicrotome
• Leica EM FC7 cryochamber
• Leica EM ICE high pressure freezer
• Leica EM AFS II freeze substitution unit 
• EMS Lynx II automated tissue processor 
• LKB 7800B glass knife maker 
• Fisher Scientific vacuum oven

Other Activities:

• Technology seminars and workshops
• Guest lectures on imaging or image analysis
• Training and troubleshooting on your microscope

Contacts