UMICH Microscopy Core

The Microscopy Core provides advanced microscopes as well as the expertise of dedicated imaging scientists.  We can assist you with every step of the imaging process from project consultation to sample preparation and through quantitative image analysis.

Our website provides a complete description of core's locations, instruments, policies, and our new rates, effective August 1^st, 2025.

Major Capabilities:

• High speed live cell imaging
• Super resolution imaging
• Large volume 3D imaging
• Intravital imaging
• Tissue clearing and expansion microscopy
• Conventional SEM and TEM sample preparation 
• Conventional SEM and TEM imaging 
• Negative staining and TEM imaging at Microscopy Core
• Immuno TEM sample preparation at Microscopy Core
• TEM tomography sample preparation at Microscopy Core
• TEM tomography imaging at MC2
• SEM array tomography sample preparation at Microscopy Core 
• SEM array tomography imaging at Microscopy Core
• Focused Ion Beam SEM sample preparation at Microscopy Core
• Focused Ion Beam SEM imaging at MC2
• High pressure freezing and freeze substitution at Microscopy Core
• Tokuyasu cryosectioning for immunolabeling 
• Correlative light and electron microscopy at Microscopy Core
• Full support for image analysis

Major Instruments:

• Nikon X1 Yokogawa spinning disk confocal
• Nikon N-SIM + A1R confocal
• Nikon A1 and A1Si confocals
• Niko Ti2 widefield
• Leica SP8 confocal + STED + MP
• Leica Stellaris confocal
• Leica SP5 confocal + MP
• Zeiss LCM 980 with Airyscan2
• Zeiss Lightsheet 7 (Gaussian lightsheet)
• Zeiss Laatice Lightsheet 7
• Jeol JEM-1400 Plus TEM 
• Zeiss EVO 15 SEM LaB6 
• EM sample preparation equipment
• Leica EM ACE600 high vacuum coater
• Lecia EM CPD300 critical point dryer
• Leica EM TRIM 2 trimmer
• Leica EM UC7 ultramicrotome
• Leica EM FC7 cryochamber
• Leica EM ICE high pressure freezer
• Leica EM AFS II freeze substitution unit 
• Leica EM TP automated tissue processor 

Other Activities:

• Consultation on instrument selection, experimental design, image acquisition and image analysis
• Technology seminars and workshops
• Guest lectures on imaging or image analysis

Contacts